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Clinical trials are the most important step in getting a drug approved by the fda Without them, no one would know if their medicines were safe The vast majority of the time, these trials go well, and the medicine is approved for general use But every once in a while, a clinical trial goes horribly wrong Keep reading to learn about 10 of these famous incidents that medical companies try. (p1), (p15),(p16),(p17) this improvement in success rates could be due to several different reasons. Over 95% of drugs fail after entering human trials, and almost 50% fail in phase 3 trials 10, 11 An estimated $150 million is spent in phase 3, while phase 1 costs on average around us$15 million. The pharmacotherapeutic landscape for ipf is moving forward with a number of new drugs currently in clinical development, mostly in phase i and ii trials, while only a few phase iii trials are running. To bridge this knowledge gap, this research investigated the differences in drug exposure between clinical trials and clinical practice. A significant number of drugs fail during the clinical testing stage