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However, understanding how long aspirin thins the blood is essential for managing dosages and anticipating potential side effects. That's why, prior to surgery, patients are told to hold off on aspirin for five to seven days, and why it continues to thin your blood even when you miss a dose, fonarow said. Aspirin is a blood thinner and low doses are recommended for certain people to prevent and treat cardiovascular issues like heart attacks and strokes Aspirin irreversibly inhibits platelets, the life of a platelet is up to 10 days, so you can see effects of asa for up to 10 days from the time it was stopped. It may also be taken for its antiplatelet effects as a blood thinning medication, which can help treat and prevent heart attack and stroke 1 it is also referred to as acetylsalicylic acid (asa) and salicylic acid. Aspirin reduces the risk of heart attacks and strokes by preventing platelets from forming blood clots on the surface of ruptured plaques Noncoated aspirin acts within minutes of ingestion to stop platelets from forming blood clots How quickly does aspirin thin blood This effect starts quite fast after taking aspirin Taking aspirin orally significantly inhibits platelet aggregation 15 minutes after intake [1] However, the time it takes aspirin to start working on the platelet is slower when the aspirin dose is lower than the full dose [2. Conclusion aspirin is a medication that has been used for many years to help relieve pain and reduce inflammation However, it also has the beneficial property of helping to thin the blood, which can prevent blood clots from forming.