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Prolactin production and release from pituitary lactotroph cells is tonically suppressed by dopamine secreted from specific neurons in the arcuate nucleus of the hypothalamus Dopamine agonists such as bromocriptine and cabergoline are the predominant treatment drugs for prolactinoma by inhibiting prolactin secretion and shrinking tumor size. Dopamine (da) holds a predominant role in the regulation of prolactin (prl) secretion The mechanical stimulation of the nipple sends signals to the hypothalamus, inhibiting dopaminergic neurons and thus removing dopamine’s suppressive effect on prolactin We will, therefore, focus on controversial aspects using personal opinion in this review Purpose prolactinomas, the predominant pituitary adenoma type, are primarily treated with dopamine agonists to decrease prolactin levels and tumor size It also possesses a more universal property In all hormonal systems studied thus far, whether at the hypothalamic, posterior pituitary, or anterior pituitary level, da functions as an. Dopamine is secreted by neurons in. Transcription of the prolactin gene is suppressed by dopaminergic activation of d2 receptors in pituitary lactotrophs The mechanism of signal transduction at the nuclear level and.Pxpi_s Leaks 2025 Photos & Videos #943
