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We also summarize the current knowledge of the dynamics of mirna action and of the secretion, transfer, and uptake of extracellular mirnas. Here, we summarize the current understanding of mirna biogenesis, function and regulation, and outline challenges to address in the future. Pirna, mirna, and sirna have in common their short length and ability to silence genes. A thorough understanding of mirna biosynthesis and the distinct pathways involved in both animal and plant cells is of paramount importance for fully elucidating the regulatory networks that control gene expression and maintain cellular homeostasis. Micrornas (mirnas), widely distributed, small regulatory rna genes, target both messenger rna (mrna) degradation and suppression of protein translation based on sequence complementarity between the mirna and its targeted mrna Although the first mirna was identified over ten years ago, it is only recently that researchers have begun to understand the scope and diversity of these regulatory molecules.