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Cultural adaptation in substance use treatment is crucial for effectively addressing the needs of diverse populations Therefore, it is essential to employ cultural humility in this work. Cultural adaptation is essential in substance abuse treatment Unlocking the power of culturally sensitive group therapy for addiction recovery Explore the impact of cultural background and treatment accessibility. Provides a general introduction to each major racial and ethnic group, providing specific cultural knowledge related to substance use and treatment Explores the concept of “drug culture” and its role in substance use disorder treatment. In order to demonstrate the application of cbpr to cultural adaptation, we present a study that developed a partnership between women in substance use treatment and academic researchers that also received support from a substance use counselor. Culturally responsive interventions are important for mitigating disparities in substance use outcomes among minoritized racial/ethnic groups, but they are poorly defined and scarcely implemented. Yet, substance use treatment is still underutilized in culturally diverse groups The first part of this chapter reviews culturally sensitive assessment measures for substance use disorders specific to screening, diagnostic evaluations, and treatment progress and outcome.